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No study has examined the effectiveness of prescribing seating modifications according to the individual clinical presentation of people with low back pain (LBP). A dynamic, forward-inclined chair (‘Back App’), can reduce seated paraspinal muscle activation among painfree participants. This study examined 21 participants whose LBP was specifically aggravated by prolonged sitting and eased by standing. Low back discomfort (LBD) and overall body discomfort (OBD) were assessed every 15 minutes while participants sat for one hour on both the dynamic, forward-inclined chair and a standard office chair. LBD increased significantly more (p=0.005) on the standard office chair, with no significant difference (p=0.178) in OBD between the chairs. The results demonstrate that, in a specific flexion-related subgroup of people with LBP, increased LBD during sitting can be minimised through modifying chair design. Mechanisms that minimise seated discomfort may be of relevance in LBP management, as part of a biopsychosocial management plan.